LIPODEX® cyclodextrin phases for enantiomer separation

Key features

  • Base material: cyclic oligosaccharides consisting of six (α-cyclodextrin), seven (β-cyclodextrin) or eight (γ-cyclodextrin) glucose units bonded through 1,4-linkages
  • Regioselective alkylation and / or acylation of the hydroxyl groups leads to lipophilic phases with varying enantioselectivity, which are well suited for GC enantiomer analysis
  • Important advantage: many compounds can be analyzed without derivatization (however, for certain substances enantioselectivity can be favorably inluenced by formation of derivatives)

    Recommended application

  • A large number of separations have been achieved, however, it is not possible to make a general prediction, which phase could solve a given separation task. Even for compounds with small structural diferences or within homologous series the enantiodiferentiation can be quite diferent.

    Note:

  • Water as solvent is strictly forbidden for all cyclodextrin phases
  • Dry the sample with CHROMAFIX® Dry (Na2SO4) cartridges
  • Use suitable nonpolar solvent