MBDSTFA - Silylation Reagent
MBDSTFA is a silylation reagent that donates a tert-butyldimethylsilyl group (TBDMS) for derivatizing active hydrogens in hydroxyl, carboxyl and thiol groups, primary and secondary amines, as well as in amino acids. Fast reactions (typically 5–20 min) with high yields (> 96 %). By-products are neutral and volatile.
TBDMS ethers are 104 times more stable than the corresponding TMS ethers. Chromatographic retention times are longer due to the large protecting group, which may improve some separations. Very useful for GC-MS applications, because of a high molecular ion concentration at M+-57 applications.
