TMSH 0.2 M in Methanol - Alkylation (Methylation) Reagent

M: 94.06 g/mol

Methylation with TMSH is recommended for free acids, chlorophenoxycarboxylic acids, their salts and derivatives as well as for phenols and chlorophenols. Lipids or triglycerides can be converted to the corresponding fatty acid methyl esters (FAMEs) by a simple transesterification. This reaction is very elegant and convenient, because it is just necessary to add the reagent (0.2 M in methanol) to the sample solution.

Removal of excess reagent is not required, since in the injector of the gas chromatograph, at 250°C, pyrolysis to volatile methanol and dimethylsulfide will occur. Due to the high reactivity, complete derivatization is often obtained at ambient temperature. However, heating (e.g., 10 min at 100°C) in a closed sample vial may be necessary to complete the reaction.