BSTFA - N,O-bis-trimethylsilyl-trifluoroacetamide

Silylation

M 257.4 g/mol, Bp 40°C (12 mm Hg), density d20°/4° = 0.961

Powerful trimethylsilyl donor with approx. the same donor strength as the nonfluorinated analog BSA Advantage of BSTFA over BSA: greater volatility of its reaction products, particularly useful for GC analysis of low boiling TMS amino acids BSTFA is nonpolar (less polar than MSTFA) and can be mixed with acetonitrile for improved solubility. For the silylation of fatty acid amides, hindered hydroxyl groups and other difficult to silylize compounds, e.g., secondary alcohols and amines, we recommend BSTFA + 1 % trimethylchlorosilane (TMCS), available under the designation SILYL-991.