MSHFBA - N-methyl-N-trimethylsilyl-heptafluorobutyramide

Silylation

M 299.1 g/mol, Bp 148°C (760 mm Hg)

Similar to MSTFA in reactivity and chromatography Recommended applications: carboxylic acids, alcohols, phenols, primary and secondary amines and amino acids; either applied alone or in combination with a catalyst (TMCS, TSIM) or another silylation reagent with or without solvent; the by-product N-methylheptafluorobutyric amide has a lower retention time than the silylating reagent; especially useful for flame ionization detection due to the large ratio of fluorine to silicon of 7:1, since degradation of the surplus MSHFBA does not produce SiO2 but volatile, non-corrosive silicon compounds