TSIM - Silylation Reagent

 

TSIM is the strongest hydroxyl silylator, the reagent of choice for carbohydrates and most steroids (even highly hindered steroids).

The reagent is unique in that it reacts quickly and smooth with hydroxyl (even tert. OH) and carboxyl groups, but not with amines. This characteristic makes TSIM particularly useful in multi-derivatization schemes for compounds with different functional groups that are to be derivatized differently, e.g., -O-TMS / -N-HFB derivatives of catecholamines.