Silylation reagent BSA - N,O-bis-trimethylsilyl-acetamide


BSA [N,O-bis(trimethylsilyl)acetamide]

M 203.4 g/mol, Bp 71-73°C (35 mm Hg), density d20°/4° = 0.832

Strong silylation reagent, creating very stable TMS derivatives of a multitude of compounds, e.g., alcohols, amines, carboxylic acids, phenols, steroids, biogenic amines and alkaloids; not recommended for use with carbohydrates or very low molecular weight compounds; good solvent for polar compounds, but frequently used in combination with a solvent (pyridine, DMF etc.) or with other silylation reagents. Dissolved in DMF, BSA is the prime derivatization reagent for phenols.