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BPA May Impact Developing Heart Valves | Chem Service Certified Reference Standards | Greyhound Chromatography

BPA May Impact Developing Heart Valves

Image of A Beating Heart

One of the main reasons why scientists have paid attention to the potential health effects of Bisphenol A is that it belongs to a class of chemical compounds known as estrogen mimics. This makes BPA significantly and potentially influential on various cells and tissues in the body, particularly during stages of embryonic development.

One team of researchers from the Carnegie Institution of Washington conducted experiments using Zebrafish that suggested BPA may impact developing heart valves, as published in the journal Environmental Health Perspectives.

Genetically modified zebrafish guide study
Estrogen and estrogen mimics control cell activity by stimulating receptors on the surfaces of cells, which then sets off a chain reaction that either activates or silences different genes within the cells' DNA.

To gain a better understanding of how BPA can affect embryonic development, the authors of the new study conducted an experiment that used genetically modified zebrafish. Alterations in the animals' genes allowed the scientists to visualize the effects of estrogen receptor activity on the DNA of cells. In general, this process makes the fish good analytical tools for water quality analysis.

With the help of green fluorescent proteins, the researchers observed that estrogenic receptor activity, which can be stimulated by BPA, can occur in the cells that form the valves of the heart. This led to questions about whether environmental exposure to estrogen mimics can drive the genesis of heart valve abnormalities.

According to the National Heart, Lung and Blood Institute, which is a division of the National Institutes of Health, heart valve problems are detrimental to blood flow. Inborn defects may make the heart valves the wrong size or shape needed for proper function. Some abnormal valves can cause backflow, in which blood flows back into the heart chamber it is supposed to leave rather than flowing forward, or stenosis, in which heart valves are too thick or stiff to open all the way to allow blood to flow into a chamber. Congenital heart valve defects are associated with both backflow and stenosis.

Currently, it may be too early to conclude whether environmental exposure to BPA causes congenital heart valve problems among humans, but the new study that used Zebrafish may lead the way for further investigations.

Over 1 million pounds released yearly
According to the U.S. Environmental Protection Agency, more than 1 million pounds of BPA are released into the environment every year. BPA is used in the manufacturing of polycarbonate plastics and epoxy resins, but humans are primarily exposed to BPA because of food packaging. Although food packaging accounts for less than 5 percent of BPA use, it can still have a major impact on human health.

The U.S. Food and Drug Administration passed several policies that banned use of the product in the manufacturing of baby bottles, sippy cups and packaging for infant formula. Such policies were not based on scientific study of the effects of BPA, but on the fact that such uses have been largely abandoned.


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Established in 1962 Chem Service is the largest independent supplier of Analytical Reference Materials and the original source of small quantities of organic chemicals. Chem Service also has over 2,000 Pesticide Standards, including Pesticide Standards for Cannabis in its catalogue.  Chem Service offers Custom made Standards manufactured to your specific requirements, all standards are accredited to ISO 17043:2016; ISO/IEC 17025:2005; ISO 9001:2015 Quality Management System.

Over 95% of Chem Services’ neat Standards Grade materials have a purity of 98.0% or greater.

Chem Services’ worldwide customers are found in the chemical, government, food quality, agricultural and life science research communities.


Pesticide Reference Standards recently added to our website: 

2,3',4',5-tetrabromodiphenyl ether(BDE 70) Solution (CAS # 446254-39-3)

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Part #:S-14273K0-1ML
CAS: 446254-39-3 

o,o,o-Tripropyl thiophosphate (CAS # 2272-08-4)

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Part #:MET-11103A-25MG
CAS: 2272-08-4


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Part #:N-14272-50MG
CAS: 304911-98-6

2,6-Dibromobiphenyl ether (BDE 10) Solution (CAS# 51930-04-2)

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Part #:S-14271K0-1ML
CAS: 51930-04-2
Classification: Polybrominated diphenyl ether
Uses: Flame retardant 
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Part #:MET-11963F-50MG
CAS: 56236-69-2

Oxathiapiprolin (CAS# 1003318-67-9)

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Part Number : N-14266-10MG

CAS#:  1003318-67-9

Chemical formula: C24H22F5N5O2S

Pesticide type: Fungicide

Substance group: Piperidinyl thiazole isoxazoline

Mode of action: Systemic, preventative with residual disease control. It acts via an oxysterol binding protein.

2-Bromodiphenyl ether (BDE 1) Solution (CAS# 7025-06-1) 

Chemical Structure Image BUY HERE

Part #:S-14267K0-1ML
CAS: 7025-06-1
Empirical Formula:  C12H9BrO
Molecular Weight: 249.10


Chlorantraniliprole (CAS # 500008-45-7) 

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Part #: N-11422-25MG 

Cas: 500008-45-7 

Molecular Formula: C18H14BrCl2N5O2 

Pesticide type: Insecticide 

Substance group: Anthranilic diamide 

Mode of action: Exhibits larvicidal activity as an orally ingested toxicant by targeting and disrupting the Ca2+ balance; Ryanodine receptor (Group 28)

Chlorantraniliprole Solution (CAS # 500008-45-7)

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Part Number: S-11422A1-1ML

Cas: 500008-45-7


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 About The Author

Susan Massie Greyhound Chromatography Image

Susan Massie, Sales & Marketing Director, Greyhound Chromatography and Allied Chemicals Email: sue@greyhoundchrom.com

Susan Massie is the Sales & Marketing Director for Greyhound Chromatography and Allied Chemicals, affectionately known as 'Greyhound' in our scientific community. Greyhound was founded by Susan's husband Paul Massie almost 40 years ago, Susan hasn't been in the business for all of that time but has been involved with Greyhound for over 17 years. Greyhound continues to grow, expanding into new markets and taking on the challenges of our ever changing environment. It's heartwarming to witness the world waking up to the fact that we are damaging our planet on a daily basis. Every action we take has a direct effect on our planet and the world we leave behind for future generations. Susan is passionate about climate change and is happy to work in an industry that can have a direct effect on reducing the impact of our actions on the environment. All of the team at Greyhound take our responsibilities very seriously, the products that we supply are used by the world's leading scientists and chemists as they endeavour to monitor and repair the environment. All is not lost, if we all take responsibility for our actions, from reducing our waste and reusing or recycling our material collateral we can make a difference. The internet is full of useful advice and guidance, Susan is proud to contribute to that wealth of knowledge whenever she can.

Greyhound prides itself on personal service which provides prompt, efficient, cost-effective, safe delivery of all products. Greyhound provides technical advice and distribution of Certified Reference Standards and Materials, Laboratory Consumables, Solvents and Reagents across all scientific disciplines. Greyhound Chromatography offers over 1 Million products from its UK warehouse. The team at Greyhound are proud to support the work of the world's leading scientists and chemists as they challenge the abuse of our planet and try to make a difference to the world we leave behind for our ancestors.

You can view Susan's Linked In Profile here https://www.linkedin.com/in/susan-massie-79ab4121/